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Plans for new Regional One campus move forward as price moves up

By , Daily Memphian Updated: August 28, 2025 9:08 AM CT | Published: August 27, 2025 8:30 PM CT

Regional One Health is moving forward with its plans to transform The Commercial Appeal’s former 16-acre campus near Downtown Memphis into a more than $1 billion full academic medical center.

It will replace Regional One’s aging campus on Jefferson Avenue with a modern facility at 495 Union Ave., which has sat vacant since the newspaper left in 2019. 

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Regional One Health rebuild Dr. Reginald Coopwood Subscriber Only

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Aisling Mäki

Aisling Mäki

Aisling Mäki covers health care, banking and finance, technology and professions. After launching her career in news two decades ago, she worked in public relations for almost a decade before returning to journalism in 2022.

As a health care reporter, she’s collaborated with The Carter Center, earned awards from the Associated Press and Society of Professional Journalists and won a 2024 Tennessee Press Association first-place prize for her series on discrepancies in Shelby County life expectancy by ZIP code.


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